proguanil hydrochloride

Malaria chemoprophylaxis

200 mg daily

Molecular weight :290.2

%Protein binding :75

%Excreted unchanged in urine : 60

Volume of distribution (L/kg) :No data

half-life – normal/ESRD (hrs) :20

20–60 100 mg daily

10 to 20 : 50 mg every 48 hours

<10 : 50 mg weekly

CAPD :Unlikely to be dialysed. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Unknown dialysability. Dose as in GFR <10 mL/min

CAV/VVHD :Unknown dialysability. Dose as in GFR 10 to 20 mL/min

Potentially hazardous interactions with other drugs

Anticoagulants: effect of warfarin possibly enhanced

Antimalarials: avoid concomitant use with artemether/lumefantrine; increased antifolate effect with pyrimethamine

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Oral

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Rare reports of haematological changes (e.g. megaloblastic anaemia and pancytopenia) in patients with severe renal impairment